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VERSION:2.0
PRODID:-//NWA Today//Events//EN
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METHOD:PUBLISH
X-WR-CALNAME:NAM-A-HOG Talk Series: Precision Genome Editing: Methods\, Mod
 els\, and Medicine
X-WR-TIMEZONE:America/Chicago
X-WR-CALDESC:NAM-A-HOG Talk Series: Precision Genome Editing: Methods\, Mod
 els\, and Medicine — (IIIR) Institute for Integrative & Innovative Resea
 rch\, Fayetteville. Via thenwatoday.com.
BEGIN:VEVENT
UID:nam-a-hog-talk-series-precision-genome-editing-methods-models-and-medic
 ine-2026-11-19@thenwatoday.com
DTSTAMP:20261110T155141Z
DTSTART;TZID=America/Chicago:20261119T123000
DTEND;TZID=America/Chicago:20261119T143000
SUMMARY:NAM-A-HOG Talk Series: Precision Genome Editing: Methods\, Models\,
  and Medicine
LOCATION:(IIIR) Institute for Integrative & Innovative Research\, Fayettevi
 lle
DESCRIPTION:Abstract: Genome editing technologies have transformed our abil
 ity to interrogate gene function\, model disease\, and develop novel thera
 peutic strategies. While genome editing technologies are conceptually stra
 ightforward\, the practical execution of precise genome engineering and mo
 del generation often requires extensive optimization\, screening\, and val
 idation. I will discuss our efforts to expand access to genome editing tec
 hnologies through the Center for Advanced Genome Engineering at St. Jude C
 hildren's Research Hospital. As a shared resource\, the center provides ex
 pertise\, infrastructure\, and standardized workflows that enable investig
 ators to efficiently implement established and emerging genome engineering
  approaches. Through these efforts\, we have validated thousands of custom
  CRISPR reagents and supported the generation of over 1500 custom engineer
 ed cell lines\, 400 preclinical animal models\, and 150 pooled CRISPR scre
 ens to support a diverse research programs. I will also describe our work 
 in developing innovative genome engineering methodologies that improve edi
 ting efficiency\, outcomes\, and scalability. By leveraging targeted deep 
 sequencing and systematic analysis of editing outcomes across thousands of
  projects\, we are generating data-driven approaches for CRISPR reagent de
 sign and optimization. Finally\, I will discuss our efforts to advance gen
 ome editing therapies for hemoglobinopathies like sickle cell disease. Tog
 ether\, these efforts illustrate how methodological innovation\, shared in
 frastructure\, and translational research can work synergistically to demo
 cratize genome editing and accelerate the development of next-generation g
 enetic medicines.\n\n \n\nAbout Shondra Pruett-Miller\, Ph.D.\n\nShondra P
 ruett-Miller\, Ph.D.\, is an Associate Member in the Department of Cell an
 d Molecular Biology at St. Jude Children's Research Hospital\, where she a
 lso serves as Founding Director of the Center for Advanced Genome Engineer
 ing and Vice President of Shared Resource
URL:https://thenwatoday.com/events/nam-a-hog-talk-series-precision-genome-e
 diting-methods-models-and-medicine-2026-11-19
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